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Phospholipase activation, free fatty acids and the proton permeability of a biological membrane
R M Lachowiez1, N M Hammoud, J L Teibel
1Department of Chemistry, State University of New York, Binghamton 13901.
FEBS Letters
|July 4, 1988
Abstract:
The rate of collapse of a proton gradient across the apical membrane of rat kidney proximal tubule increases upon treatment with calcium, mercuric chloride and mellitin, substances which activate phospholipase A2. Treatment with phospholipase A2 or oleic acid also enhances the rate of proton gradient dissipation. Membrane water permeability is not affected. This phenomenon may have implications in pathological states arising from ischemia or toxic exposure.