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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is critical for...

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Related Experiment Video

Updated: Jul 16, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Epigenetic Regulation of Memory-Therapeutic Potential for Disorders.

Padmanabh Singh1, Sweta Srivas1, M K Thakur1

  • 1Biochemistry and Molecular Biology Laboratory, Brain Research Centre, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221 005, India.

Current Neuropharmacology
|April 11, 2017
PubMed
Summary

Epigenetic modifications regulate memory by altering gene expression. Targeting these reversible changes offers therapeutic potential for memory loss in aging and neurodegenerative diseases.

Keywords:
DNA methylationEnzyme inhibitorsGene expressionHistone acetylationHistone methylationMemory

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Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
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Quantification of Global Histone Post Translational Modifications Using Intranuclear Flow Cytometry in Isolated Mouse Brain Microglia

Published on: September 15, 2023

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Memory function declines with aging and neurodegenerative diseases.
  • Synaptic plasticity gene expression is crucial for memory formation and consolidation.
  • Epigenetic modifications are key regulators of synaptic plasticity and neuronal function.

Purpose of the Study:

  • To review the role of epigenetic regulation in memory.
  • To explore the therapeutic potential of targeting epigenetic modifications for memory dysfunction.

Main Methods:

  • Compilation and discussion of research reports and online content.
  • Focus on epigenetic regulation of memory in physiological and pathological conditions.

Main Results:

  • Epigenetic modifications include DNA methylation/hydroxymethylation and histone acetylation/methylation.
  • These epigenetic marks are altered during memory formation and impairment.
  • Epigenetic modifications are reversible and can be modulated by enzyme inhibitors.

Conclusions:

  • Epigenetic modifications are implicated in memory disorders.
  • Targeting epigenetic mechanisms offers therapeutic potential for memory recovery.
  • Exploiting epigenetic modifications could treat memory dysfunction in aging and neurological disorders.