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Updated: Aug 12, 2026
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Expression of E-cadherin and B-cell lymphoma 2 in oral cancer: A ratio-based planning for targeted therapy
Nikita Gulati1, Ajit Singh Rathore1, Saurabh Juneja1
1Department of Oral and Maxillofacial Pathology and Microbiology, ITS Dental Collge, Ghaziabad, Uttar Pradesh, India.
Background:
Oral cancer is known to be governed by the antiapototic and loss of cell adhesion properties which dictate its progression.
Aim:
To study the immunexpression of E-cadherin and Bcl-2 in varying TNM stages and histopathological grades of OSCC.
Materials And Methods:
11 cases of well differentiated, 10 cases of moderately differentiated and 11 cases of poorly differentiated OSCC were studied immunohistochemically using archival paraffin embedded tissue specimens.
Statistical Analysis:
Differences between the different variables were analyzed using ANOVA test, Kruskal-Wallis test and post hoc test followed by Bonferroni test. The resulting data was analyzed using SPSS software version 19.
Results:
The expression of Bcl-2 and E cadherin immunopositivity was associated positively with tumor grade, high T category and Histopathological grades.
Conclusions:
The results of this study points to the significance of cell proliferation and invasion as a major determinant of prognosis in OSCC.
