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[Neurological disorders associated with gluten sensitivity].

D A Degterev1, I V Damulin2, A I Parfenov1

  • 1Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.

Terapevticheskii Arkhiv
|April 11, 2017
PubMed
Summary

This review covers neurological disorders linked to gluten sensitivity, focusing on gluten ataxia and polyneuropathy. It details clinical symptoms and the impact of a gluten-free diet on these conditions.

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Area of Science:

  • Neurology
  • Immunology
  • Dietary Science

Background:

  • Gluten sensitivity can manifest with diverse neurological complications.
  • Gluten ataxia and polyneuropathy are the most prevalent neurological disorders associated with gluten sensitivity.

Purpose of the Study:

  • To review the pathogenesis, clinical presentation, and treatment of neurological disorders in gluten sensitivity.
  • To elucidate the clinical features and dietary management of gluten-related neurological conditions.

Main Methods:

  • Literature review of pathogenetic, clinical, and therapeutic aspects.
  • Analysis of clinical manifestations in gluten-sensitive neurological disorders.
  • Evaluation of the impact of gluten-free diets.

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Main Results:

  • Neurological disorders are a significant manifestation of gluten sensitivity.
  • Gluten ataxia and polyneuropathy present distinct clinical features.
  • A gluten-free diet can ameliorate neurological symptoms in affected individuals.

Conclusions:

  • Gluten sensitivity necessitates comprehensive neurological assessment.
  • Early diagnosis and adherence to a gluten-free diet are crucial for managing neurological complications.
  • Further research into the pathomechanisms is warranted.