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Directed adenine functionalization for creating complex architectures for material and biological applications.

Balaram Mohapatra1, Pratibha, Sandeep Verma

  • 1Department of Chemistry Indian Institute of Technology Kanpur, Kanpur, India. sverma@iitk.ac.in.

Chemical Communications (Cambridge, England)
|April 11, 2017
PubMed
Summary

This article details design strategies for modified nucleobases to create advanced materials like metal-organic frameworks (MOFs) and nanoparticles. These materials have diverse applications, including drug delivery and environmental remediation.

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Medicinal Chemistry

Background:

  • Purine and pyrimidine derivatives possess versatile coordination chemistry and inherent noncovalent interaction capabilities.
  • These nucleobase derivatives can bind various metal ions, enabling the construction of complex supramolecular structures.
  • Their biocompatibility opens avenues for biological applications.

Purpose of the Study:

  • To outline targeted design strategies for modified adenine nucleobase derivatives.
  • To explore the construction of diverse metal-mediated supramolecular architectures and advanced materials.
  • To highlight the broad application spectrum of these designed constructs.

Main Methods:

  • Utilizing the rich chemistry of purine and pyrimidine derivatives for ligand design.

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  • Employing metal ions to mediate the formation of discrete complexes, coordination polymers, and metal-organic frameworks (MOFs).
  • Leveraging hydrogen bonding and π-π interactions to stabilize resulting frameworks and nanoparticles.

    • Main Results:

    • Successful construction of metal-mediated discrete complexes, ring-expanded purine skeletons, coordination polymers, and shape-selective MOFs.
    • Development of purine-capped nanoparticles with potential for gas/solvent adsorption, bioimaging, and anticancer therapies.
    • Demonstration of stable frameworks and network solids through noncovalent interactions.

    Conclusions:

    • Targeted design strategies for modified nucleobases are effective in creating advanced functional materials.
    • The versatility of purine derivatives in coordination and noncovalent interactions facilitates the development of diverse supramolecular structures.
    • These materials show significant promise for applications ranging from environmental remediation to biomedical uses.