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Amidation of unactivated ester derivatives mediated by trifluoroethanol
Christopher G McPherson1, Nicola Caldwell, Craig Jamieson
1Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK. craig.jamieson@strath.ac.uk.
Organic & Biomolecular Chemistry
|April 11, 2017
Abstract:
A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.