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Related Experiment Videos

[Encapsulating peritoneal sclerosis].

Rubén Torres1, Paula Ebner1, María Eugenia Sanhueza1

  • 1Sección de Nefrología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, Chile.

Revista Medica De Chile
|April 11, 2017
PubMed
Summary

Encapsulating peritoneal sclerosis (EPS) is a severe complication of peritoneal dialysis (PD). Early suspicion based on symptoms like abdominal pain and high transport is crucial for managing this condition.

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Area of Science:

  • Nephrology
  • Gastroenterology

Background:

  • Encapsulating peritoneal sclerosis (EPS) is a rare but fatal complication of peritoneal dialysis (PD).
  • It involves peritoneal inflammation, fibrosis, and intestinal encapsulation.
  • Risk factors include prolonged PD duration, peritonitis, high glucose solutions, and high peritoneal transport.

Purpose of the Study:

  • To describe the clinical characteristics of patients undergoing PD who developed EPS.

Main Methods:

  • Retrospective review of medical records for 12 patients diagnosed with EPS.
  • Analysis of clinical manifestations, diagnostic findings, and treatment outcomes.

Main Results:

  • Patients averaged 98 months on PD.
  • Common symptoms included abdominal pain (82%) and ultrafiltration failure (63%).

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  • Most had a history of peritonitis (92%) and high peritoneal transport (75%). CT scans showed peritoneal calcification and thickening; biopsy confirmed diagnosis in 10 cases.
  • Treatment involved PD withdrawal, catheter removal, and medications (corticoids, tamoxifen). 50% improved, while others experienced persistent symptoms; 17% mortality.

    • Conclusions:

    • EPS is a serious PD complication.
    • Suspect EPS in PD patients with compatible symptoms, prolonged PD use, recurrent peritonitis, and high peritoneal transport.
    • Timely diagnosis and management, including PD cessation, can improve outcomes.