Related Experiment Video
Updated: Oct 8, 2026

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
Published on: January 22, 2021
Antibiotic treatment failure when consulting patients with respiratory tract infections in general practice. A
Margrethe Bordado Sköld1, Rune Aabenhus1, Ann Dorrit Guassora1
1a Center for Education and Research in General Practice, Department of Public Health, Faculty of Health Sciences , University of Copenhagen , Copenhagen , Denmark.
Background:
Prescribing antibiotics for acute respiratory tract infections (RTIs) is common in primary healthcare although most of these infections are of viral origin and antibiotics may not be helpful. Some of these prescriptions will not be associated with a quick recovery, and might be regarded as cases of antibiotic treatment failure (ATF).
Objectives:
We studied antibiotic treatment failure in patients with acute RTIs from a general practitioner (GP) perspective, aiming to explore (i) GPs' views of ATF in primary care; (ii) how ATF influences the doctor-patient relationship; and (iii) GPs' understanding of patients' views of ATF.
Methods:
Qualitative study based on semi-structured, recorded interviews of 18 GPs between August and October 2012. The interviews started with discussion of a unique case of acute RTI involving ATF, followed by a more general reflection of the topic. Interviews were analysed using qualitative content analysis.
Results:
In patients with acute RTIs, GPs proposed and agreed to a medical definition of antibiotic treatment failure but believed patients' views to differ significantly from this medical definition. GPs thought ATF affected their daily work only marginally. GPs used many communicative tools to maintain trust with patients in cases of ATF, but they did not consider such incidents to affect the doctor-patient relationship adversely.
Conclusion:
These findings suggest a possible communication gap between doctors and patients, partly due to a narrow medical definition of ATF. Studies describing patients' views are still missing. General practitioners' experiences and views on antibiotic treatment failure in acute respiratory infections or its effects on the doctor-patient relationship have not been studied previously.
Insights
General practitioners (GPs) define antibiotic treatment failure (ATF) medically, but believe patients have different views. GPs use communication strategies to maintain trust, suggesting a potential gap in understanding ATF in acute respiratory infections.
Area of Science:
- Primary healthcare research
- Infectious disease management
- Qualitative research methods
Background:
- Antibiotic prescribing for acute respiratory tract infections (RTIs) is prevalent in primary care, despite many RTIs being viral.
- A subset of antibiotic prescriptions for RTIs may be perceived as antibiotic treatment failure (ATF) due to lack of rapid recovery.
Purpose of the Study:
- To explore general practitioners' (GPs) perspectives on antibiotic treatment failure (ATF) in primary care.
- To investigate the influence of ATF on the doctor-patient relationship.
- To understand GPs' perceptions of patients' views regarding ATF.
Main Methods:
- Qualitative study involving semi-structured interviews with 18 GPs.
- Interviews focused on a specific case of acute RTI with ATF, followed by general reflections.
- Data analyzed using qualitative content analysis.
Main Results:
- GPs agreed on a medical definition of ATF but perceived a significant difference in patient understanding.
- GPs reported minimal impact of ATF on their daily work.
- Communicative strategies were employed to maintain patient trust, with no perceived adverse effect on the doctor-patient relationship.
Conclusions:
- A potential communication gap exists between doctors and patients regarding ATF, possibly due to differing definitions.
- Further research is needed to understand patients' views on ATF.
- This study is the first to examine GPs' experiences and views on ATF in acute respiratory infections and its impact on the doctor-patient relationship.
Related Concept Videos
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
Urine Studies II: Urine Culture and Sensitivity Test
Microbiota of the Respiratory Tract
Microbiota Modulation by Antibiotics
Mechanism of Antibiotic Resistance in MRSA
Clinical Significance of Antibiotic Resistance

