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Abnormal wiring of CCK+ basket cells disrupts spatial information coding
Isabel Del Pino1,2, Jorge R Brotons-Mas2, André Marques-Smith1,3
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom.
Nature Neuroscience
|April 11, 2017
Summary
The tyrosine kinase receptor ErbB4 is crucial for integrating cholecystokinin (CCK)+ basket cells into cortical circuits. This integration is vital for spatial learning and memory, impacting theta oscillations and place cell coding.
Area of Science:
- Neuroscience
- Cellular Neuroscience
- Systems Neuroscience
Background:
- Cortical GABAergic interneurons' function depends on neural circuit integration.
- Mechanisms governing the wiring of these interneurons, especially cholecystokinin (CCK)-expressing basket cells, are poorly understood.
Purpose of the Study:
- To investigate the role of the tyrosine kinase receptor ErbB4 in the circuit integration of CCK-expressing basket cells.
- To determine the impact of ErbB4-mediated wiring on hippocampal spatial coding and behavior.
Main Methods:
- Utilized conditional mice lacking ErbB4 in specific neuronal populations.
- Assessed synaptic connectivity, inhibitory drive onto pyramidal cells, and theta oscillations.
- Analyzed spatial learning and memory deficits in adult mice.
Main Results:
- ErbB4 is essential for the normal integration of CCK+/VGlut3+ basket cells into cortical circuits.
- Loss of ErbB4 reduced inhibitory synapses and drive from these cells onto pyramidal neurons.
- Disrupted connectivity impaired theta oscillations, spatial coding, and spatial memory.
Conclusions:
- ErbB4 signaling is critical for the proper wiring and function of CCK+ basket cells.
- Normal integration of these interneurons into cortical networks is fundamental for hippocampal spatial coding and memory processes.