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Related Experiment Video

Updated: Jun 22, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

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Published on: August 30, 2017

The retrosplenial cortex and object recency memory in the rat.

Anna L Powell1, Seralynne D Vann1, Cristian M Olarte-Sánchez1

  • 1School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK.

The European Journal of Neuroscience
|April 11, 2017
PubMed
Summary

The retrosplenial cortex is involved in object recency memory, distinguishing between

Keywords:
c-foshippocampusrecognition memorysubiculumtemporal discrimination

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Memory Research

Background:

  • The retrosplenial cortex (RSC) is theorized to be part of a 'where/when' information processing network.
  • Its potential role in 'what/when' information, specifically object recency memory, remains less understood.

Purpose of the Study:

  • To investigate the RSC's contribution to 'what/when' information processing, focusing on object recency memory.
  • To determine if RSC lesions impair temporal order memory for objects.

Main Methods:

  • Experiment 1: Rats with retrosplenial lesions performed object recency tasks under 'Within-Block' and 'Between-Block' conditions.
  • Experiment 2: Immediate-early gene c-fos expression was mapped in intact rats' RSC during a 'Between-Block' recency task.

Main Results:

  • Rats with retrosplenial lesions were impaired in 'Within-Block' but not 'Between-Block' recency discrimination.
  • Recency memory performance correlated positively with c-fos expression in granular and dysgranular RSC (areas 29 and 30).
  • RSC c-fos activity correlated with prelimbic cortex and ventral subiculum activity, which also related to memory performance.

Conclusions:

  • The retrosplenial cortex plays a role in both 'Within-Block' and 'Between-Block' temporal order memory.
  • The RSC is part of a network, including the hippocampal formation, medial diencephalon, and medial frontal cortex, crucial for recency memory.
  • These findings support the RSC's significant role in both 'what/when' and 'where/when' information processing due to its interconnectedness.