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The respiratory burst oxidase
1Division of Biochemistry, Research Institute of Scripps Clinic, La Jolla, California.
Hematology/Oncology Clinics of North America
|June 1, 1988
Abstract:
The respiratory burst oxidase is an activatable, membrane-bound flavo(?hemo) protein that catalyzes the NADPH-dependent reduction of oxygen to superoxide (O2-) in stimulated phagocytes. Chronic granulomatous disease, a group of disorders in which phagocytes cannot manufacture O2-, is caused by a biochemical lesion involving this oxidase or its activating system.