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Development of Recombinant Proteins to Treat Chronic Pain
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Published on: April 11, 2018

Rab7-a novel redox target that modulates inflammatory pain processing.

Wiebke Kallenborn-Gerhardt1,2, Christine V Möser2, Jana E Lorenz2

  • 1Institute of Pharmacology, College of Pharmacy, Goethe University, Frankfurt am Main, Germany.

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|April 11, 2017
PubMed
Summary

Reactive oxygen species (ROS) contribute to chronic pain. This study identifies Rab7, a small GTPase, as a key redox-modified target in sensory neurons, revealing its role in modulating inflammatory pain.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pain Research

Background:

  • Chronic pain involves reactive oxygen species (ROS) in nociceptive processing.
  • Molecular targets of ROS signaling in pain pathways are not well understood.

Purpose of the Study:

  • To identify molecular targets of redox regulation in pain pathways.
  • To investigate the role of the small GTPase Rab7 in inflammatory pain.

Main Methods:

  • Proteome screen using OxICAT to identify redox-modified proteins.
  • Investigated Rab7 GTPase activity upon modification of redox-sensing thiols.
  • Utilized immunofluorescence and knockout mice lacking Rab7 in sensory neurons.

Main Results:

  • Rab7 was identified as a redox-modified target during inflammatory pain.
  • Rab7 oxidation influences its GTPase activity.
  • Reduced inflammatory pain behavior was observed in mice lacking Rab7 in sensory neurons.

Conclusions:

  • Redox-dependent modification of Rab7 activity modulates inflammatory pain sensitivity.
  • Rab7 is a novel molecular player in ROS-mediated pain signaling.