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Related Experiment Videos

Physiological mechanisms associated with ovulation prediction using the CUE Ovulation Predictor.

R S Fernando1, J Regas, G Betz

  • 1Zetek, Inc., Aurora, CO 80011.

Human Reproduction (Oxford, England)
|May 1, 1988
PubMed
Summary

Salivary electrical resistance (SR) monitoring can predict ovulation. Adrenocorticotrophic hormone (ACTH) influences aldosterone (ALDO) levels, which in turn alter salivary electrolytes, causing changes in SR preceding ovulation.

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Area of Science:

  • Reproductive endocrinology
  • Hormonal regulation
  • Biomarker discovery

Background:

  • Salivary electrical resistance (SR) monitoring predicts ovulation 5-6 days before the luteinizing hormone (LH) peak.
  • Previous hypotheses involving estrogen and aldosterone (ALDO) do not fully explain the observed SR changes.
  • Sodium trends in milk during ovulation parallel SR changes, suggesting a common regulatory mechanism.

Purpose of the Study:

  • To investigate the physiological mechanisms underlying pre-ovulatory changes in salivary electrical resistance (SR).
  • To explore the role of hormones, specifically adrenocorticotrophic hormone (ACTH) and aldosterone (ALDO), in modulating SR.
  • To establish a potential link between ACTH, ALDO, and SR for ovulation prediction.

Main Methods:

Related Experiment Videos

  • Review of physiological pathways, including the estrogen-aldosterone-renin-angiotensin system.
  • Analysis of reported trends in salivary sodium and milk sodium.
  • Correlation of preliminary data on ACTH, ALDO, and SR levels in normally ovulating subjects.

    • Main Results:

    • The estrogen-aldosterone pathway does not account for the pre-ovulatory SR peak and decline.
    • Changes in SR appear to be linked to fluctuations in aldosterone levels, similar to sodium trends in milk.
    • Preliminary data show coincidental peaks in ACTH, ALDO, and SR occurring 6 days before the LH peak.

    Conclusions:

    • ACTH likely influences aldosterone secretion, thereby modifying salivary electrolytes and electrical resistance.
    • This ACTH-aldosterone-salivary electrolyte pathway provides a plausible mechanism for the observed pre-ovulatory SR changes.
    • ACTH, ALDO, and SR serve as potential biomarkers for predicting ovulation several days in advance.