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Innate immunity in Sjögren's syndrome
Jeremy Kiripolsky1, Liam G McCabe1, Jill M Kramer2
1Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214, United States.
Clinical Immunology (Orlando, Fla.)
|April 12, 2017
Summary
Sjögren's syndrome (SS) involves innate immune hyperactivity. Dysregulated innate immune cells and pathways in patients and mouse models drive SS pathogenesis, offering new therapeutic targets.
Area of Science:
- Immunology
- Rheumatology
- Autoimmune Diseases
Background:
- Sjögren's syndrome (SS) is an autoimmune disease affecting exocrine glands, causing dry eyes and mouth, with systemic manifestations.
- Innate immune system hyperactivity is a key feature in many autoimmune conditions, including SS.
Purpose of the Study:
- To review the role of the innate immune system in Sjögren's syndrome pathogenesis.
- To discuss the etiology of SS, focusing on innate immune dysfunction.
- To explore emerging therapies targeting innate immune pathways in SS.
Main Methods:
- Review of existing literature on SS pathogenesis and innate immunity.
- Analysis of findings from SS mouse models and human patient studies.
- Examination of innate immune cells, pathways, and dysregulation mechanisms.
Main Results:
- Innate immune dysregulation is a critical driver of SS pathogenesis, observed in both mouse models and patients.
- Specific innate immune cells and signaling pathways are implicated in SS inflammation.
- Dysregulation occurs in both exocrine tissues and peripheral blood of SS patients.
Conclusions:
- The innate immune system plays a central role in Sjögren's syndrome development and progression.
- Understanding innate immune dysfunction provides insights into SS etiology.
- Targeting innate immune signaling pathways represents a promising therapeutic strategy for SS.