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Biological Age Predictors.

Juulia Jylhävä1, Nancy L Pedersen1, Sara Hägg1

  • 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Ebiomedicine
|April 12, 2017
PubMed
Summary
This summary is machine-generated.

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Researchers are exploring biomarkers for biological age, not just chronological age. Epigenetic clocks show promise, but require more study to confirm their value in predicting aging.

Area of Science:

  • Biomarkers of Aging
  • Molecular Biology
  • Gerontology

Background:

  • Reliable biological age indicators have been sought for over 30 years.
  • Molecular biology advances offer new potential biomarkers.
  • Distinguishing biological from chronological age is crucial for aging research.

Purpose of the Study:

  • To review current state-of-the-art biological age predictors.
  • To summarize findings on epigenetic, telomere, transcriptomic, proteomic, metabolomic, and composite biomarkers.
  • To highlight promising developments in aging research.

Main Methods:

  • Literature review of current scientific findings.
  • Analysis of six categories of potential biological age predictors.
  • Evaluation of combined biomarker approaches.
Keywords:
AgingBiomarkerEpigenetic clockPredictionTelomere length

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Main Results:

  • Epigenetic clocks are currently the most promising biological age predictor.
  • Telomere length, transcriptomics, proteomics, metabolomics, and composite predictors are also discussed.
  • Combinations of predictors may offer deeper insights into aging.

Conclusions:

  • Epigenetic clocks show significant potential as biological age biomarkers.
  • Longitudinal studies are necessary to validate the predictive power of epigenetic clocks.
  • Further research into composite biomarkers may advance understanding of healthy aging.