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Related Experiment Videos

Chronic ambulatory electrocorticography from human speech cortex.

Vikram R Rao1, Matthew K Leonard2, Jonathan K Kleen1

  • 1University of California, San Francisco, Department of Neurology, San Francisco, CA 94143, United States.

Neuroimage
|April 12, 2017
PubMed
Summary
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The NeuroPace RNS System, initially for epilepsy, can now record long-term brain activity related to speech and cognition. This breakthrough enables studying natural human brain function over extended periods.

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Biomedical Engineering

Background:

  • Direct intracranial recordings offer insights into cognition but are limited by duration and patient constraints.
  • Existing methods provide only brief snapshots of brain activity in artificial settings.
  • The NeuroPace RNS System, designed for epilepsy, offers continuous intracranial recording capabilities.

Purpose of the Study:

  • To evaluate the potential of the NeuroPace RNS System for recording behavior-related neural activity over long timescales.
  • To demonstrate the system's ability to capture meaningful physiological responses in naturalistic settings.
  • To investigate the neural correlates of speech processing and production using long-term intracranial recordings.

Main Methods:

  • Utilized the NeuroPace RNS System with intracranial electrodes implanted over Wernicke's and Broca's areas in two human subjects.
Keywords:
Broca's areaChronic electrocorticographyECoGHumanRNS SystemWernicke's area

Related Experiment Videos

  • Recorded cortical evoked responses to spoken sentences and word production during a naming task.
  • Analyzed the stability and selectivity of recorded neural signals over nearly 1.5 years.

    • Main Results:

    • Cortical responses to spoken sentences in Wernicke's area were robust, phonetically selective, and stable over 1.5 years.
    • Word production in Broca's area reliably evoked pre-speech cortical responses.
    • The RNS System demonstrated high spatiotemporal resolution and signal-to-noise ratio for intracranial recordings.

    Conclusions:

    • The NeuroPace RNS System is a powerful tool for long-term, ambulatory intracranial recording of human brain activity.
    • This technology enables novel investigations into the neural basis of cognition in naturalistic environments.
    • The findings open new avenues for understanding complex cognitive functions over extended durations.