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Related Experiment Video

Updated: Jun 24, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Multi-chamber microfluidic platform for high-precision skin permeation testing.

M Alberti1, Y Dancik2, G Sriram3

  • 1Singapore Institute of Manufacturing Technology, A*STAR, 2 Fusionopolis Way, Level 10, Innovis, 138634 Singapore. yuri.dancik@imb.a-star.edu.sg zpwang@simtech.a-star.edu.sg.

Lab on a Chip
|April 12, 2017
PubMed
Summary

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This summary is machine-generated.

A new microfluidic skin permeation device offers a more sensitive and reproducible alternative to traditional Franz diffusion cells for chemical absorption and toxicity testing.

Area of Science:

  • Pharmacology
  • Toxicology
  • Cosmetic Science
  • Microfluidics
  • Skin-on-chip technology

Background:

  • Static Franz diffusion cells are the standard in vitro method for assessing chemical skin absorption and penetration.
  • However, Franz cells are expensive, have low throughput, and can yield inconsistent results.
  • Microfluidic technology presents a promising alternative to address these limitations.

Purpose of the Study:

  • To introduce and validate a novel microfluidic skin permeation platform.
  • To compare its performance against the established static Franz diffusion cell.
  • To demonstrate its utility for chemical transport studies and toxicity screening.

Main Methods:

  • Development of a novel microfluidic skin permeation device.

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Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
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Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

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Last Updated: Jun 24, 2026

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Published on: October 1, 2007

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
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A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

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  • Rigorous validation against static Franz diffusion cells.
  • Comparison of transport for three model chemicals (caffeine, salicylic acid, testosterone) with varying lipophilicity.
  • Experiments conducted using both silicone membranes and organotypic skin cultures.

    • Main Results:

    • The microfluidic chip demonstrated higher sensitivity in measuring cumulative permeant amounts.
    • The chip achieved comparable or lower coefficients of variation than Franz cells.
    • Experiments with organotypic skin cultures showed the microfluidic device reduces the impact of unstirred water layers.
    • The device effectively models chemical transport across skin barriers.

    Conclusions:

    • The novel microfluidic platform provides a more efficient, sensitive, and reproducible method for in vitro skin permeation studies.
    • This technology has the potential to significantly advance skin absorption and toxicity screening.
    • Further development of microfluidic skin-on-chip devices is warranted for broader applications in drug discovery and cosmetic science.