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Elevated β-hCG associated with aggressive Osteoblastoma.

Carol D Morris1, Meera R Hameed2, Narasimhan P Agaram2

  • 1Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, The Johns Hopkins Hospital, 601 North Caroline Street, Baltimore, MD, 21287, USA. cmorri61@jhmi.edu.

Skeletal Radiology
|April 12, 2017
PubMed
Summary
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A rare aggressive scapular osteoblastoma in a young woman produced beta-human chorionic gonadotropin (β-hCG), mimicking pregnancy and delaying treatment. Surgical removal normalized β-hCG levels, confirming the paraneoplastic phenomenon.

Area of Science:

  • Oncology
  • Endocrinology
  • Orthopedic Surgery

Background:

  • Osteoblastoma is a rare bone tumor, typically benign, but can exhibit aggressive behavior.
  • Paraneoplastic syndromes involve substances produced by tumors that affect distant tissues or bodily functions.
  • Beta-human chorionic gonadotropin (β-hCG) is a hormone primarily associated with pregnancy and certain cancers.
Keywords:
Beta-human chorionic gonadotropinOsteoblastoma, paraneoplasticβ-hCG

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