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Updated: Aug 19, 2026
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
Does the patients age at cancer diagnosis affect microvessels density in uterine sarcoma tissues?
Marcin Bobiński1, Wiesława Bednarek, Karolina Okła
11st Chair and Department of Gynecological Oncology and Gynecology, Medical University of Lublin, Poland. m.s.bobinski@gmail.com.
Objectives:
The objective of the study was to retrospectively evaluate the density of vessels exhibiting positive glycoprotein CD34 expression in the uterine leiomyosarcoma tissues and their correlation with the age of patients at the time of tumor diagnosis.
Material And Methods:
The archival paraffin blocks with the cancer tissues collected from 50 patients suffering from uterine leiomyosarcoma were used together with their clinical and demographic data. The immunohistochemical peroxidase-de-pendent methods were used to detect microvessels with positive CD34 expression. The glycoprotein CD34 expression was evaluated as a density of microvessel showing the positive immunohistochemical reaction (MVDCD34).
Results:
The negative, statistically significant correlation between the age of patients (at the moment diagnosis) and the MVDCD34+ (R = -0.289, p = 0.042) was found.
Conclusions:
The study's findings may suggest that the tissues of younger people constitute a permissive environment for pro-angiogenic factors.
