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Primary Squamous Cell Carcinoma of the Thyroid: A Population-Based Analysis
Joshua K Au1,2, Jose Alonso1, Edward C Kuan1,2
11 Department of Head and Neck Surgery, UCLA Medical Center, Los Angeles, California, USA.
Summary
Primary squamous cell carcinoma of the thyroid is a rare cancer with a poor prognosis. Surgical treatment improves overall survival, with age, tumor grade, and size being key prognostic factors.
Area of Science:
- Oncology
- Epidemiology
- Surgical Oncology
Background:
- Primary squamous cell carcinoma of the thyroid is an exceptionally rare malignancy.
- Understanding its epidemiology and prognostic factors is crucial for patient management.
Purpose of the Study:
- To analyze the epidemiology of primary squamous cell carcinoma of the thyroid.
- To identify prognostic indicators for patients diagnosed with this rare cancer.
Main Methods:
- Retrospective cohort study utilizing the US National Cancer Institute's SEER registry (1973-2012).
- Analysis included patient demographics, tumor characteristics, treatment modalities, overall survival (OS), and disease-specific survival (DSS).
Main Results:
- 199 cases were identified; mean age 68.1 years, 58.3% female, 79.4% white.
- Five-year OS and DSS were 16% and 21%, respectively; median survival was 9.1 months.
- Age, tumor grade, and tumor size significantly predicted OS and DSS. Surgery predicted OS but not DSS.
Conclusions:
- Primary squamous cell carcinoma of the thyroid is a rare cancer with a very poor prognosis.
- Surgical resection offers a survival benefit.
- Age, tumor grade, and tumor size are significant predictors of survival.