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Updated: Jul 29, 2026

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
Published on: May 9, 2018
Biopsy-proven hypersensitivity pneumonitis caused by a fluorocarbon waterproofing spray
G I Walters1, S Trotter2, B Sinha3
1Occupational Lung Disease Service, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK.
Background:
We present the case of a 35-year-old male who developed a chronic hypersensitivity pneumonitis (HP) following inhalational exposure to a fluorocarbon waterproofing aerosol spray, caused by his work for an upholstery and soft furnishings retailer. This is the first case report from inhalational fluorocarbon exposure with histological evidence of chronic HP. This is then discussed in the context of previous reports of interstitial lung disease and lung injury, caused by similar occupational and non-occupational exposures.

