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Related Experiment Videos

Sweeteners and sweetness enhancers.

Christine Belloir1, Fabrice Neiers, Loïc Briand

  • 1AgroSup Dijon, CNRS, INRA, Université de Bourgogne-Franche Comté, Centre des Sciences du GoÛt et de l'Alimentation, Dijon, France.

Current Opinion in Clinical Nutrition and Metabolic Care
|April 12, 2017
PubMed
Summary

Sweeteners and sweetness enhancers are perceived by the T1R2/T1R3 taste receptor, found in both the mouth and extraoral tissues. Understanding sugar substitutes is crucial for evaluating their potential health effects.

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Area of Science:

  • Sensory Science
  • Molecular Biology
  • Physiology

Background:

  • Sweet taste perception is mediated by the T1R2/T1R3 receptor in the oral cavity.
  • This receptor identifies diverse sweet compounds, including natural sugars, sugar alcohols, and artificial sweeteners.
  • The T1R2/T1R3 receptor is also expressed in numerous extraoral tissues.

Purpose of the Study:

  • To review and discuss current knowledge on sweeteners and sweetness enhancers.
  • To explore the physiological impact of various sweeteners.
  • To highlight the role of the T1R2/T1R3 receptor in sweet taste perception and beyond.

Main Methods:

  • Literature review of scientific articles on sweeteners and sweetness enhancers.
  • Analysis of the molecular mechanisms of sweet taste perception.

Related Experiment Videos

  • Discussion of the physiological roles and extraoral expression of the T1R2/T1R3 receptor.

    • Main Results:

    • The T1R2/T1R3 receptor recognizes a wide array of sweet-tasting compounds.
    • Sweeteners exhibit significant chemical diversity.
    • Functional T1R2/T1R3 receptors are present in various extraoral tissues, suggesting broader physiological roles.

    Conclusions:

    • Sweeteners and sweetness enhancers are perceived via the T1R2/T1R3 taste receptor in both oral and extraoral locations.
    • Current knowledge on sugar substitutes necessitates an examination of their potential health implications.