Thermogenesis by THADA
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Nirmalya Chatterjee1, Norbert Perrimon2
1Department of Genetics, Harvard Medical School, Boston, MA 02115.
Developmental Cell
|April 12, 2017
Abstract:
THADA has been associated with cold adaptation and diabetes in humans, but the cellular and molecular basis of its function has been unknown. Moraru and colleagues (2017) report in this issue of Developmental Cell that it triggers thermogenesis by uncoupling ATP hydrolysis from calcium transport into the endoplasmic reticulum.