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Polyol monoterpenes isolated from Chenopodium ambrosioides
Shu-Qun Hou1, Yan-Hong Li1, Xiang-Zhong Huang1
1a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine , Yunnan Minzu University , Kunming , P. R. China.
Natural Product Research
|April 13, 2017
Summary
Two new polyol monoterpenes were identified from Chenopodium ambrosioides. Compound 1 demonstrated moderate anti-inflammatory activity by inhibiting nitric oxide production in macrophages.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Chenopodium ambrosioides is a plant used in traditional medicine.
- Monoterpenes are a diverse class of natural products with various biological activities.
- Inflammation is a complex biological response implicated in numerous diseases.
Purpose of the Study:
- To conduct a phytochemical investigation of Chenopodium ambrosioides stems.
- To isolate and characterize new and known compounds from the plant extract.
- To evaluate the anti-inflammatory potential of the isolated compounds.
Main Methods:
- Extraction of plant material using 95% ethyl alcohol.
- Isolation of compounds using chromatographic techniques.
- Structure elucidation of new compounds utilizing extensive 1D and 2D NMR spectroscopy.
- In vitro anti-inflammatory assay using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
Main Results:
- Two novel polyol monoterpenes, compounds 1 and 2, were isolated and characterized.
- Five known monoterpenes (compounds 3-7) were also identified.
- Compound 1 exhibited moderate inhibition of nitric oxide (NO) production with an IC50 value of 16.83 μM against LPS-stimulated RAW 264.7 macrophages.
Conclusions:
- The phytochemical analysis of Chenopodium ambrosioides yielded new polyol monoterpenes.
- Compound 1 possesses anti-inflammatory properties, suggesting potential therapeutic applications.
- Further research is warranted to explore the full pharmacological profile and mechanism of action of compound 1.