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Vectorized nanodelivery systems for ischemic stroke: a concept and a need.
Andrés Da Silva-Candal1, Bárbara Argibay1, Ramón Iglesias-Rey1
1Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitario, Universidade de Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS), c/Travesa da Choupana, s/n, 15706, Santiago de Compostela, Spain.
Journal of Nanobiotechnology
|April 13, 2017
Summary
Neuroprotection faces challenges in clinical application. Nanotechnology offers a promising path for personalized brain protection strategies, improving treatment for neurological diseases.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Nanotechnology
Background:
- Neurological diseases significantly impair patient quality of life due to the brain's limited self-repair capacity.
- The progressive and irreversible nature of many neurological conditions necessitates effective neuroprotective strategies.
- Current experimental neuroprotective approaches face significant obstacles in human implementation.
Purpose of the Study:
- To review obstacles hindering clinical translation of neuroprotective strategies.
- To propose alternative therapeutic avenues for neuroprotection.
- To highlight the role of nanotechnology in advancing personalized neuroprotection.
Main Methods:
- Review of existing literature on neuroprotection and nanotechnology in neurological diseases.
- Analysis of challenges in translating experimental neuroprotection to clinical practice.
- Exploration of nanotechnology-based solutions for stroke and other neurological conditions.
Main Results:
- Nanotechnology enables highly specific and localized biomedical solutions for studying neurological disease mechanisms.
- Nanotechnology facilitates personalized neuroprotection by identifying mechanisms and optimal therapeutic windows.
- Nanotechnology aids in protecting patients from brain damage, particularly in stroke.
Conclusions:
- Overcoming current obstacles requires innovative approaches to neuroprotection.
- Nanotechnology presents a transformative approach for personalized neuroprotection and brain repair.
- Further in vivo and in vitro studies are crucial to enhance the clinical applicability of nanotechnology in neuroprotection.