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Identification of short single disulfide-containing contryphans from the venom of cone snails using de novo mass
Jayaseelan Benjamin Franklin1, Rajaian Pushpabai Rajesh2, Nambali Valsalan Vinithkumar1
1Andaman and Nicobar Centre for Ocean Science and Technology, National Institute of Ocean Technology, Ministry of Earth Sciences, Government of India, Dollygunj, Port Blair 744103, India.
Abstract:
We identified 12 short single disulfide-containing conopeptides from the venom of Conus coronatus, C. leopardus, C. lividus and C. zonatus. Interestingly, we detected the shortest contryphan sequence thus far characterized which contains only six amino acid residues. We also identified three distinct contryphan sequences of C. lividus without any proline residues and one sequence with an unusual post-translational modification (bromination of tryptophan). Furthermore, we characterized venom peptides of C. zonatus for the first time.