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Related Experiment Videos

Cardiotoxicity with Itraconazole.

Vishesh Paul1, Harsh Rawal2

  • 1Univeristy of Illinois Urbana-Champaign, Urbana, Illinois, USA visheshpaul@gmail.com.

BMJ Case Reports
|April 13, 2017
PubMed
Summary

Itraconazole, an antifungal, may cause heart failure. Two cases of acute systolic heart failure were reported in patients using this medication, highlighting a potential cardiac risk.

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Area of Science:

  • Pharmacology
  • Cardiology
  • Infectious Diseases

Background:

  • Itraconazole is a widely prescribed antifungal agent.
  • While known for common side effects, its association with heart failure is infrequently reported.
  • This study investigates potential cardiac adverse events linked to itraconazole therapy.

Observation:

  • Two male patients presented with symptoms of acute systolic heart failure, including dyspnea and edema.
  • Both patients were undergoing treatment with itraconazole for fungal infections (blastomycosis and cellulitis).
  • Cardiac evaluations revealed significantly reduced ejection fractions in both individuals.

Findings:

  • No alternative causes for heart failure were identified in either patient despite comprehensive cardiac investigations.
  • One patient experienced persistent heart failure requiring advanced treatment, while the other showed improvement after itraconazole discontinuation.
  • The severity of heart failure and recovery varied between the two cases.

Implications:

  • These cases suggest a potential causal link between itraconazole use and the development of acute systolic heart failure.
  • Clinicians should consider monitoring cardiac function in patients receiving itraconazole, especially those with pre-existing cardiac risk factors.
  • Further research is warranted to elucidate the mechanisms and prevalence of itraconazole-induced cardiotoxicity.
Keywords:
Heart failureUnwanted effects / adverse reactions

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