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Peripherin diverts ciliary ectosome release to photoreceptor disc morphogenesis
Robert S Molday1, Andrew F X Goldberg2
1Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada molday@mail.ubc.ca goldberg@oakland.edu.
The Journal of Cell Biology
|April 13, 2017
Abstract:
Formation of membrane discs in photoreceptor cells requires evagination of its ciliary plasma membrane by an unknown molecular mechanism. Salinas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608081) show that peripherin (also known as peripherin-2 or peripherin-2/rds) diverts membrane traffic to photoreceptor disc formation by inhibiting ectosome release from the cilium.