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Shining the Light on Senescence Associated LncRNAs
A R Ghanam1, Qianlan Xu2, Shengwei Ke2
11CAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.; 2Collage of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
Aging and Disease
|April 13, 2017
Summary
Cellular senescence is a stress response causing permanent cell cycle arrest, implicated in aging and tumor suppression. This review covers senescence forms, biomarkers, and the role of long noncoding RNAs (lncRNAs).
Area of Science:
- Cellular and Molecular Biology
- Gerontology
- Oncology
Background:
- Cellular senescence is a stress-induced, irreversible cell cycle arrest.
- Initially observed in cultured cells, it's now recognized as a programmed response to various stresses.
- Senescence plays roles in tumor suppression, aging, and tissue repair.
Purpose of the Study:
- To review diverse forms of cellular senescence.
- To discuss current biomarkers for identifying senescent cells in vitro and in vivo.
- To highlight the significance of senescence-associated long noncoding RNAs (lncRNAs).
Main Methods:
- Literature review of cellular senescence.
- Analysis of senescence-associated biomarkers.
- Examination of the role of lncRNAs in senescence.
Main Results:
- Cellular senescence is a complex biological process with implications in aging and cancer.
- Various biomarkers exist for detecting senescent cells in vitro and in vivo.
- Senescence-associated lncRNAs are emerging as critical players in this process.
Conclusions:
- Cellular senescence is a multifaceted process involved in fundamental biological functions.
- Understanding senescence biomarkers and lncRNAs is crucial for future research and therapeutic strategies.
- Further investigation into lncRNAs' role in senescence may unlock new avenues for age-related disease and cancer treatment.