Successful retreatment with combined BRAF/MEK inhibition in metastatic BRAFV600-mutated melanoma
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V C Amann1,2, D Hoffmann3, J Mangana1
1Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Background:
The combination treatment with BRAF and MEK inhibitors is amongst the current standard of care for stage IIIC/IV BRAF-mutated melanoma. However, therapeutic options are limited once patients have progressed upon both targeted and immunotherapy.
Objective:
To investigate whether retreatment with BRAF and MEK inhibitor combination is an option for patients with metastatic BRAF-mutated melanoma upon previous progression on kinase inhibitors.
Methods:
Two patients with metastatic BRAF-mutated melanoma were rechallenged with BRAF and MEK inhibitor combination after progression on targeted therapy and subsequent immunotherapy with anti-CTLA-4 and anti-PD-1 antibodies.
Results:
Both patients responded to retreatment. Responses were limited to a few months and associated with a considerable increase in quality of life.
Conclusion:
Retreatment with BRAF and MEK inhibitors may present a feasible treatment option upon progression on both kinase inhibitors and immunotherapy, and should be considered when all other treatment options have been exhausted.