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Biophysical Stimulation for Engineering Functional Skeletal Muscle.

Sarah M Somers1,2, Alexander A Spector1,2,3, Douglas J DiGirolamo4

  • 11 Department of Biomedical Engineering, Johns Hopkins University School of Medicine , Baltimore, Maryland.

Tissue Engineering. Part B, Reviews
|April 13, 2017
PubMed
Summary

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This summary is machine-generated.

Biomimetic tensile strain enhances skeletal muscle tissue engineering by improving stem cell differentiation and graft function. Optimizing strain protocols is key for developing functional muscle grafts.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cellular Mechanobiology

Background:

  • Current ex vivo skeletal muscle tissue engineering yields grafts with poor contractile function.
  • Low stem cell differentiation efficiency is a major limitation in current methods.

Purpose of the Study:

  • To review integrin-dependent mechanisms linking mechanotransduction to myogenic gene upregulation.
  • To analyze strain protocols for optimizing skeletal muscle tissue engineering.

Main Methods:

  • Review of literature on biomimetic tensile strain application in vitro.
  • Analysis of strain parameters: orientation, amplitude, frequency, duration, and rest periods.
  • Examination of cell types including stem cells and myoblasts.
Keywords:
biophysical cuesbioreactorsmechanotransductionskeletal muscletensile strain

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Main Results:

  • Biomimetic tensile strain significantly enhances myogenic differentiation and skeletal muscle graft function.
  • Uniaxial strain may be more effective than biaxial strain for muscle regeneration.
  • Optimizing strain regimens requires considering cells, biomaterials, and bioreactors in tandem for 3D systems.

Conclusions:

  • Biomimetic tensile strain is a potent stimulus for engineering functional skeletal muscle.
  • Further research is needed to refine strain parameters for optimal ex vivo cultivation.
  • Integrated system design is crucial for successful 3D skeletal muscle tissue engineering.