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Synthesis of N-Propargylsulfoximines by Copper-Catalyzed A3 -Couplings
Hanchao Cheng1, Jian Wen1, Carsten Bolm1
1Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 13, 2017
Abstract:
An efficient synthesis of N-propargylsulfoximines was developed through a copper-catalyzed coupling of aldehydes, alkynes, and NH-sulfoximines. The reaction requires no co-catalyst or ligand and shows a wide substrate scope with moderate to good yields.