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Related Experiment Videos

Mining prokaryotes for antimicrobial compounds: from diversity to function.

Vittorio Tracanna1, Anne de Jong2, Marnix H Medema1

  • 1Bioinformatics Group, Wageningen University, Droevendaalsesteeg 1, Radix West, Building 107, 6708 PB Wageningen, The Netherlands.

FEMS Microbiology Reviews
|April 13, 2017
PubMed
Summary

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Bacteria are a rich source of antimicrobials. Advanced genomic and ecological mining approaches accelerate the discovery of novel antimicrobial molecules from diverse natural products.

Area of Science:

  • Microbiology
  • Natural Product Chemistry
  • Drug Discovery

Background:

  • The bacterial kingdom is a significant source of antimicrobial compounds.
  • Increasing omics data (genomic, metabolomic, transcriptomic) presents opportunities for antimicrobial discovery.
  • Existing antimicrobials face challenges from resistance, necessitating novel drug development.

Purpose of the Study:

  • To review powerful mining approaches for identifying novel antimicrobial molecules.
  • To highlight diverse natural product classes, including peptides and polyketides.
  • To discuss both direct and integrative mining strategies.

Main Methods:

  • Mining of bacterial genomes for biosynthetic gene clusters.
  • Ecology-based mining strategies.
Keywords:
NRPSPKSRiPPantimicrobialbacteriabiosyntheticevolutiongene clustersgenomemining

Related Experiment Videos

  • Functionality-based and mode-of-action-based mining approaches.
  • Analysis of structurally diverse natural products.

    • Main Results:

    • Identification of novel antimicrobial molecules from bacterial sources.
    • Application of advanced computational and experimental mining techniques.
    • Potential for discovering new drug scaffolds and lead compounds.

    Conclusions:

    • Integrative mining approaches enhance the discovery of novel antimicrobials.
    • Bacterial natural products remain a promising resource for new drug development.
    • Accelerated discovery of antimicrobial drugs is achievable through advanced mining strategies.