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General Approaches to Structurally Diverse Isocyanoditerpenes.

Mary Elisabeth Daub1, Philipp C Roosen1, Christopher D Vanderwal1

  • 1Department of Chemistry, University of California , 1102 Natural Sciences II, Irvine, 92697-2025 California, United States.

The Journal of Organic Chemistry
|April 14, 2017
PubMed
Summary
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Isocyanoterpenes, natural products with unique structures, show potent antiplasmodial activity. This study reviews synthetic strategies for these compounds, including recent advancements in their synthesis.

Area of Science:

  • Organic Chemistry
  • Natural Product Synthesis
  • Medicinal Chemistry

Background:

  • Isocyanoterpenes are natural products discovered in the 1970s.
  • They possess unique molecular architectures and isonitrile functional groups.
  • Recent findings highlight their significant in vitro antiplasmodial activity.

Purpose of the Study:

  • To review synthetic strategies for isocyanoterpenes.
  • To highlight diverse approaches targeting structurally different members of this compound class.
  • To present recent contributions to isocyanoterpene synthesis.

Main Methods:

  • Discussion of three distinct synthetic strategies.
  • Focus on methods addressing multiple isocyanoterpene structures.
  • Inclusion of recent synthetic methodologies developed by the authors' group.

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Main Results:

  • Overview of successful synthetic routes to various isocyanoterpenes.
  • Demonstration of the applicability of discussed strategies to different structural types.
  • Presentation of novel synthetic contributions.

Conclusions:

  • The development of efficient synthetic strategies is crucial for accessing isocyanoterpenes.
  • These synthetic efforts are driven by the compounds' biological activities, particularly antiplasmodial effects.
  • Continued research in synthetic organic chemistry enables the exploration of complex natural products.