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Related Experiment Videos

Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: A meta-analysis of randomized

Chuangang Peng1, Chen Li, Ji Qu

  • 1Department of Orthopedics, The Second Hospital of Jilin University, Changchun, People's Republic of China.

Medicine
|April 14, 2017
PubMed
Summary

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Gabapentin effectively reduces postoperative pain and morphine use after spine surgery. Higher doses (≥900 mg/d) show greater efficacy, though more research is needed.

Area of Science:

  • Anesthesiology
  • Neurosurgery
  • Pharmacology

Background:

  • Postoperative pain is prevalent in ~80% of spinal surgery patients.
  • Gabapentin is frequently used in enhanced recovery programs for acute pain management.
  • This meta-analysis evaluates gabapentin's efficacy and safety in post-spinal surgery pain.

Purpose of the Study:

  • To assess the effectiveness of gabapentin in managing postoperative pain after spinal surgery.
  • To determine the impact of gabapentin on total morphine consumption.
  • To evaluate the safety profile and associated complications of gabapentin use.

Main Methods:

  • A systematic literature search was performed across multiple databases (PubMed, EMBASE, Web of Science, Cochrane, Google).
  • Included studies compared gabapentin with placebo in spine surgery patients.

Related Experiment Videos

  • Primary outcomes: Visual Analog Scale (VAS) pain scores at 12 & 24 hours, total morphine consumption. Secondary outcomes: incidence of nausea, dizziness, somnolence, headache, pruritus, urine retention, vomiting.

    • Main Results:

    • Seven studies with 581 patients were analyzed.
    • Gabapentin significantly reduced VAS pain scores at 12 & 24 hours and total morphine consumption.
    • Gabapentin decreased the incidence of vomiting (RR 0.46), urine retention (RR 0.57), and pruritus (RR 0.38), with no significant effect on nausea, dizziness, somnolence, or headache.

    Conclusions:

    • Gabapentin is effective for reducing postoperative pain, morphine consumption, and related complications after spine surgery.
    • High-dose gabapentin (≥900 mg/d) appears more effective than low-dose regimens.
    • Further research is recommended due to the limited number of included studies.