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Anatomo-radiological correlation using 18-FDG-PET in abdominal sepsis model in rats. A preliminary study
Ítalo Medeiros Azevedo1, Marília Daniela Ferreira Carvalho1, Rafael Pereira Nascimento2
1Fellow PhD degree, Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte (UFRN), Natal-RN, Brazil. Acquisition and interpretation of data, technical procedures, manuscript preparation.
Purpose::
To examine a correlation of micro-PET images with photographic images of the digestive organs in abdominal sepsis model.
Methods::
Male Wistar rats weighing 265±18g were used. Abdominal sepsis was induced by ligature and cecal puncture. Micro-PET Images from abdominal cavity septic foci were obtained using 18-Fluoro-deoxyglucose, looking for a correlation with photographic images of abdominal cavity organs. Pearson's correlation test was used.
Results::
The mean standard uptake values (SUV) and lesion areas were 2.58±0.63SUVbwg/ml and 546.87±300.95mm2, respectively. There was a strong positive correlation between the two variables (r=0.863, p=0.137), which resulted in a coefficient of determination r2?0.75, meaning that 75% of SUV variation is explained by the lesion areas of digestive organs.
Conclusion::
Micro-PET allows high throughput assessment of lesion count and volume in pre-clinical rat model of CPL abdominal sepsis.