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[Neutralization by bioantioxidants of virus-induced mutagenesis in cultured human cells]

A A Aliev, A B Shekhtman, A I Asadova

    Genetika
    |April 1, 1988
    PubMed

    Insights

    Alpha-tocopherol, a form of vitamin E, demonstrated antimutagenic properties against viral infections. This antioxidant neutralized mutations induced by West Nile virus and poliovirus in cell cultures.

    Area of Science:

    • Biochemistry
    • Virology
    • Cell Biology

    Context:

    • Viral infections can induce cellular mutations.
    • Antioxidants may counteract these effects.
    • Alpha-tocopherol (vitamin E) is a known antioxidant.

    Purpose:

    • To investigate the antimutagenic potential of alpha-tocopherol.
    • To determine if alpha-tocopherol can neutralize viral-induced mutations.
    • To assess the effect of administration timing on alpha-tocopherol's efficacy.

    Summary:

    • Alpha-tocopherol effectively neutralized mutations caused by persistent West Nile virus and primary poliovirus infections in transplanted amnion and human kidney cells.
    • The study demonstrated an antimutagenic effect of alpha-tocopherol.
    • This effect was observed regardless of the timing or sequence of alpha-tocopherol and viral inductor application.

    Impact:

    • Provides evidence for the protective role of alpha-tocopherol against viral-induced mutagenesis.
    • Suggests potential therapeutic applications of vitamin E in managing viral infections.
    • Highlights the stability of alpha-tocopherol's protective effect against different viral strains and infection patterns.

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