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Potential Molecular Targets of Ampelopsin in Prevention and Treatment of Cancers
Xianjuan Kou1, Jingjing Fan1, Ning Chen1
1Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079. China.
Abstract:
Cancers have increased threat to human health due to the limited treatment efficacy of chemotherapy and radiotherapy with a series of toxicity and side effects; therefore, the development and utilization of natural products with potential preventive and therapeutic efficacy, and less toxicity and side effects will be beneficial to promote the health of cancer patients. In this article, the activity of ampelopsin as a natural flavonoid and its underlying molecular mechanisms for the prevention and treatments of hepatic carcinoma, breast cancer, prostate cancer and melanoma through inhibiting cell proliferation, accelerating apoptosis, inducing reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress, suppressing angiogenesis, invasion and metastasis, and synergizing the efficacy of other anti-cancer drugs have been summarized. This study will provide a reference for the development and utilization of other natural products.
Insights
Ampelopsin, a natural flavonoid, shows potential in preventing and treating various cancers. It works by inhibiting cancer cell growth, promoting cell death, and reducing metastasis, offering a less toxic alternative to traditional therapies.
Area of Science:
- Natural product chemistry
- Cancer biology
- Pharmacology
Background:
- Cancer poses a significant global health threat, with chemotherapy and radiotherapy exhibiting limited efficacy and considerable toxicity.
- There is a growing need for novel, less toxic therapeutic agents, particularly those derived from natural sources.
- Natural products offer a promising avenue for developing effective cancer prevention and treatment strategies.
Purpose of the Study:
- To summarize the anticancer activities of ampelopsin, a natural flavonoid.
- To elucidate the molecular mechanisms underlying ampelopsin's efficacy against various cancer types.
- To provide a reference for the development of natural products in cancer therapy.
Main Methods:
- Literature review of studies investigating ampelopsin's effects on cancer cells.
- Analysis of molecular mechanisms including cell proliferation, apoptosis, reactive oxygen species (ROS) generation, endoplasmic reticulum (ER) stress, angiogenesis, invasion, and metastasis.
- Evaluation of ampelopsin's synergistic effects with other anti-cancer drugs.
Main Results:
- Ampelopsin demonstrated inhibitory effects on cell proliferation across hepatic carcinoma, breast cancer, prostate cancer, and melanoma.
- The compound was shown to accelerate apoptosis, induce ROS generation, and trigger ER stress in cancer cells.
- Ampelopsin suppressed angiogenesis, invasion, and metastasis, and enhanced the efficacy of conventional anti-cancer drugs.
Conclusions:
- Ampelopsin exhibits broad-spectrum anticancer properties through multiple molecular pathways.
- Its ability to inhibit cancer progression and synergize with existing treatments highlights its therapeutic potential.
- Ampelopsin serves as a valuable natural product for further research and development in oncology.