Related Experiment Video
Updated: Aug 4, 2026

06:18
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Contraception during perimenopause: The spermicides option]
1Hôpital Saint-Louis, 75010 Paris, France.
Journal of Gynecology Obstetrics and Human Reproduction
|April 14, 2017
Summary
Spermicides can be a suitable contraceptive option for perimenopausal women, especially those with contraindications to other methods. Further research is needed to confirm their efficacy and acceptability in this age group.
Area of Science:
- Reproductive Health
- Contraception
- Gynecology
Background:
- Perimenopausal women face increased health risks, impacting contraceptive choices.
- Traditional contraceptive methods may have contraindications for this demographic.
Purpose of the Study:
- To evaluate the benefits of spermicides for women in perimenopause.
- To assess spermicides as a contraceptive option for women over 40.
Main Methods:
- Review of national and international contraceptive guidelines.
- Literature review on spermicide efficacy and side-effects (benzalkonium chloride, nonoxynol-9).
- Focus on the over-40 age group.
Main Results:
- No contraceptive methods are contraindicated for women over 40.
- Spermicide efficacy varies, with no age-specific differences noted.
- Spermicides are suitable for perimenopausal women, particularly those with contraindications or unwillingness to use other methods. Some offer a lubricant effect.
Conclusions:
- Spermicides should be discussed in contraceptive counseling for women over 40.
- Evidence-based information on spermicide use, efficacy, and safety is crucial.
- Further studies on spermicide efficacy and acceptability in this age group are warranted.
Related Concept Videos
Meiosis II
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each containing...
Gonadal and Placental Hormones
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
Ovarian Cycle
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Menopause
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Birth Control Methods
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...
Intrauterine Drug Delivery Systems
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

