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Molecular endoscopy for targeted imaging in the digestive tract
Jeong Hoon Lee1, Thomas D Wang2
1Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
The Lancet. Gastroenterology & Hepatology
|April 14, 2017
Summary
Molecular endoscopy combines optical imaging with molecular probes for early gastrointestinal cancer detection. This advanced technique visualizes molecular targets, improving disease understanding and therapeutic guidance.
Area of Science:
- Gastroenterology and Molecular Imaging
Background:
- Endoscopy offers high-resolution, non-destructive optical imaging of digestive tract mucosal surfaces.
- Molecular imaging is crucial for early cancer detection and therapy guidance by visualizing molecular targets.
- Understanding disease mechanisms requires observing molecular target expression patterns.
Purpose of the Study:
- To review the fundamental concepts of molecular endoscopy.
- To summarize key findings from preclinical and clinical molecular endoscopy studies.
- To highlight the potential of molecular endoscopy for gastrointestinal disease intervention.
Main Methods:
- Utilizing optical imaging methods with a broad wavelength range for tissue investigation.
- Developing prototype devices for collecting fluorescence for wide-field and microscopic imaging.
- Administering various targeting moieties (probes, antibodies, peptides, lectins) in vivo.
Main Results:
- Prototype devices have been developed for molecular imaging.
- Successful preclinical and clinical studies have utilized various targeting moieties.
- Molecular endoscopy provides insights into molecular events in signaling pathways.
Conclusions:
- Molecular endoscopy is a powerful tool for visualizing mucosal surfaces and molecular targets.
- Emerging technologies offer new approaches to study molecular events in gastrointestinal diseases.
- Molecular endoscopy holds promise for improved prevention and treatment strategies.