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Related Experiment Videos

β-endorphin immunoreactivity during anaesthesia in equidae.

P M Taylor1, Spl Luna2, A Dye3

  • 1Department of Clinical Veterinary Medicine, University of Cambridge, UK.

Veterinary Anaesthesia and Analgesia
|April 14, 2017
PubMed
Summary

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Anesthesia and surgery significantly increase plasma beta-endorphin immunoreactivity (BEI) in horses, indicating a stress response. Halothane and hypoxia caused greater BEI increases than pentobarbitone anesthesia.

Area of Science:

  • Equine Anesthesiology
  • Endocrinology
  • Veterinary Pharmacology

Background:

  • Plasma beta-endorphin immunoreactivity (BEI) is a marker of the endocrine stress response.
  • Understanding BEI fluctuations during anesthesia is crucial for equine welfare.

Purpose of the Study:

  • To investigate the impact of anesthesia, hypoxia, hypercapnia, and flunixin on plasma BEI in horses.
  • To assess the role of surgical stress on BEI levels in equine anesthesia.

Main Methods:

  • Prospective crossover study involving ponies and horses.
  • Horses underwent anesthesia with guaifenesin, thiopentone, and halothane, or surgery.
  • Plasma samples analyzed for BEI using radio-immunoassay; statistical analysis via ANOVA.
Keywords:
Anaesthesiahorsestress responseβ-endorphin immunoreactivity

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Main Results:

  • Anesthesia induction increased plasma BEI 5-10 fold, except in the hypercapnia group.
  • Halothane anesthesia elevated BEI; pentobarbitone anesthesia did not significantly alter BEI.
  • Hypoxia and surgery induced the highest BEI levels, suggesting significant physiological stress.

Conclusions:

  • Beta-endorphin is a sensitive indicator of endocrine stress during equine anesthesia.
  • The precise physiological role of BEI during equine anesthesia remains to be elucidated.