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Summary
This review examines fluid and macromolecule movement across microvascular, interstitial, and lymphatic spaces. It aims to inform rational intravenous colloid therapy based on physiological principles.
Area of Science:
- Physiology
- Pathophysiology
- Pharmacology
Background:
- Understanding fluid and macromolecular dynamics is crucial for effective medical interventions.
- The interplay between microvascular, interstitial, and lymphatic systems governs fluid balance.
Purpose of the Study:
- To elucidate the pathophysiology of fluid and macromolecular transport.
- To establish a framework for evidence-based intravenous colloid administration.
Main Methods:
- Comprehensive literature search of Medline (1966-present) and CAB abstracts (1973-present).
- Inclusion of personal files for a thorough review.
Main Results:
- Detailed review of physiological mechanisms governing fluid and macromolecule exchange.
- Identification of key factors influencing transvascular and lymphatic transport.
Conclusions:
- A strong understanding of fluid dynamics supports rational colloid therapy.
- Physiological principles should guide the selection and use of intravenous colloids.