Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Opening borders for foreign bodies.

Christopher M Jewell1

  • 1Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.

Science Translational Medicine
|April 14, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microparticles synthesized from itaconate polyesters enable metabolite delivery and elicit immunoregulatory outcomes.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Integrating molecular dynamics simulations to enable rational assembly of immune signals for immunotherapy.

Nanoscale horizons·2026
Same author

PEGylation strategies for enhanced nanoparticle delivery to tumor-associated immune cells.

Bioengineering & translational medicine·2026
Same author

Optimizing genetic engineering approaches for protein loading into bacterial extracellular vesicles for vaginal drug delivery.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial.

Nature medicine·2026
Same author

BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial.

Nature medicine·2026
Same journal

CAR T cell therapy selectively depletes disease-driving mutant calreticulin cells in xenotransplants and human organoid models of myelofibrosis.

Science translational medicine·2026
Same journal

Bioresponsive microneedle stent provides anastomosis and postoperative adjuvant therapy in preclinical resectable intestinal diseases.

Science translational medicine·2026
Same journal

Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.

Science translational medicine·2026
Same journal

KSHV-infected endothelial cells expand and up-regulate angiogenic pathways and CXCR4 in patient-derived Kaposi sarcoma models.

Science translational medicine·2026
Same journal

Hypoxia-driven T cell-macrophage-stromal cross-talk sustains fibrosis in preclinical models of cutaneous chronic graft-versus-host disease.

Science translational medicine·2026
Same journal

Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models.

Science translational medicine·2026
See all related articles

Targeting macrophage receptors can prevent fibrosis, a key factor in the failure of implantable biomedical devices. This approach enhances the host immune response to foreign materials.

Area of Science:

  • Biomedical Engineering
  • Immunology
  • Materials Science

Background:

  • Implantable biomedical devices often fail due to fibrotic processes.
  • Fibrosis is a host immune response to foreign bodies.
  • Macrophage-specific receptors play a crucial role in this immune response.

Purpose of the Study:

  • To investigate the potential of targeting macrophage-specific receptors.
  • To eliminate fibrotic processes associated with biomedical device failure.
  • To improve the longevity and efficacy of implantable devices.

Main Methods:

  • Identifying and characterizing macrophage-specific receptors involved in foreign body response.
  • Developing strategies to target these identified receptors.
  • Evaluating the impact of receptor targeting on fibrotic tissue formation in vitro and in vivo.

Related Experiment Videos

Main Results:

  • Successful identification of key macrophage receptors mediating fibrosis.
  • Demonstration that targeting these receptors significantly reduces fibrotic encapsulation.
  • Improved biocompatibility and reduced foreign body reaction observed with targeted interventions.

Conclusions:

  • Targeting macrophage-specific receptors is a viable strategy to mitigate fibrosis.
  • This approach holds promise for enhancing the performance and success of biomedical implants.
  • Further research can lead to novel therapeutic interventions for device-related complications.