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Updated: Aug 5, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Sarcoidosis : Renal manifestations]
1V. Medizinische Klinik, Nephrologie, Endokrinologie, Rheumatologie, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland. christian.loeffler@umm.de.
Zeitschrift Fur Rheumatologie
|April 14, 2017
Summary
Renal sarcoidosis is common and often asymptomatic, requiring active investigation. Early diagnosis and treatment with corticosteroids are crucial for managing kidney disease and preventing relapse.
Area of Science:
- Nephrology
- Rheumatology
- Immunology
Background:
- Renal involvement in sarcoidosis is underrecognized, with many patients asymptomatic.
- Traditional epidemiological data may underestimate the prevalence of kidney disease in sarcoidosis.
Purpose of the Study:
- To highlight the importance of actively screening for renal involvement in sarcoidosis.
- To outline diagnostic and therapeutic strategies for renal sarcoidosis.
Main Methods:
- Review of current literature and clinical guidelines.
- Emphasis on diagnostic work-up including urinalysis, renal function tests, and renal biopsy.
- Discussion of treatment modalities.
Main Results:
- Renal sarcoidosis is frequently detected only upon specific investigation.
- Renal biopsy is essential for assessing disease type, severity, and prognosis.
- Corticosteroids are the primary treatment, with steroid-sparing agents having limited evidence.
Conclusions:
- Systematic screening for renal involvement is vital in all sarcoidosis patients.
- Prompt diagnosis and appropriate immunosuppressive therapy, primarily corticosteroids, are key.
- Discontinuation of therapy carries a significant risk of disease relapse.
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