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Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
Published on: September 22, 2017
[Maculopathy with optic nerve pits : Morphological criteria in SD-OCT].
K Wehrmann1, S Stumpfe2, M Pettenkofer2
1Augenklinik, Klinikum rechts der Isar, TU München, Ismaningerstrasse 22, 81675, München, Deutschland. klaus.wehrmann@mri.tum.de.
Summary
Optic pit maculopathy causes remain unclear. High-resolution OCT reveals vitreous changes, suggesting prepapillary liquefaction and pressure gradients are key factors in optic pit maculopathy development.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Congenital Eye Anomalies
Background:
- Optic pit is a congenital optic disc anomaly.
- Optic pit maculopathy etiology is debated.
- Vitreoretinal interface abnormalities are implicated.
Purpose of the Study:
- Investigate vitreoretinal and vitreopapillary changes in optic pit eyes.
- Utilize high-resolution Optical Coherence Tomography (OCT).
- Clarify the cause of optic pit maculopathy.
Main Methods:
- Analyzed 12 eyes with optic pits using Spectral Domain OCT (SD-OCT).
- Assessed vitreoretinal and vitreo-papillary transitions.
- Identified criteria: vitreous liquefaction, papillary vitreous traction, hyaloid cortex discontinuity, and communication spaces.
Main Results:
- Communication gaps between pit and edema in 8 eyes.
- Papillary vitreous traction in 4 eyes.
- Hyaloid cortex discontinuity in 4 eyes.
- Two eyes showed no maculopathy but had adjacent papillary vitreous without prepapillary liquefaction.
- All eyes exhibited some stage of vitreous liquefaction.
Conclusions:
- The exact cause of optic pit maculopathy is not fully understood.
- High-resolution OCT provides detailed vitreoretinal assessment.
- Prepapillary liquefaction and pressure gradients may be crucial factors.
