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Related Experiment Videos

Perineurial calcification.

R H King1, J G Llewelyn, P K Thomas

  • 1Department of Neurological Science, Royal Free Hospital School of Medicine, London, UK.

Neuropathology and Applied Neurobiology
|March 1, 1988
PubMed
Summary

Extracellular calcium deposits are more common in abnormal human sural nerves, especially those affected by diabetic neuropathy. This suggests a link between diabetes and nerve calcification, likely due to metabolic changes.

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Area of Science:

  • Neurology
  • Pathology
  • Biochemistry

Background:

  • Extracellular calcification can occur in various tissues.
  • The perineurium of peripheral nerves is a potential site for such deposits.
  • Diabetic neuropathy is a common complication of diabetes mellitus.

Purpose of the Study:

  • To investigate the occurrence and incidence of extracellular calcium deposits in the perineurium of human sural nerves.
  • To compare calcification rates in normal nerves versus those from patients with neuropathies, particularly diabetic neuropathy.
  • To elucidate the potential mechanisms and contributing factors to perineurial calcification in diabetic neuropathy.

Main Methods:

  • Histological examination of human sural nerve biopsies.
  • Analysis of extracellular deposits within the perineurium.

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  • Comparison of calcification incidence across different nerve conditions.

    • Main Results:

    • A higher incidence of extracellular calcium deposits was observed in abnormal sural nerves compared to normal nerves.
    • Nerves from patients with diabetic neuropathy exhibited the highest incidence of perineurial calcification among the conditions studied.
    • Calcification likely involves deposition on matrix vesicles or lipid droplets, potentially originating from perineurial cells.

    Conclusions:

    • The perineurium of human sural nerves is susceptible to extracellular calcification.
    • Diabetic neuropathy is strongly associated with an increased incidence of perineurial calcification.
    • Metabolic abnormalities associated with diabetes mellitus are likely responsible for the heightened calcification in diabetic neuropathy.