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Monocytes and macrophages in abdominal aortic aneurysm
Juliette Raffort1,2,3,4, Fabien Lareyre1,4,5, Marc Clément1
1Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, West Forvie Building, Forvie Site, Robinson Way, Cambridge CB2 0SZ, UK.
Nature Reviews. Cardiology
|April 14, 2017
Summary
Understanding monocytes and macrophages in abdominal aortic aneurysm (AAA) is key. Distinct subsets play critical roles in AAA initiation, progression, and healing, offering potential new therapeutic targets.
Area of Science:
- Cardiovascular Biology
- Immunology
- Vascular Medicine
Background:
- Abdominal aortic aneurysm (AAA) is a life-threatening condition with high mortality upon rupture.
- Current treatments focus on surgical or endovascular repair, with a lack of effective drug-based therapies.
- AAA pathogenesis involves extracellular matrix remodeling, smooth muscle cell loss, and significant inflammation.
Purpose of the Study:
- To review the molecular and cellular mechanisms underlying AAA formation and progression.
- To specifically focus on the involvement of monocytes and macrophages in AAA.
- To explore potential translational applications for detecting and imaging macrophage subsets in AAA.
Main Methods:
- Review of experimental and clinical studies on monocyte and macrophage roles in AAA.
- Analysis of the origin, functions, and subsets of monocytes and macrophages in AAA.
- Evaluation of translational applications for clinical practice.
Main Results:
- Monocytes and macrophages are crucial inflammatory cells in AAA development and complications.
- Distinct monocyte and macrophage subsets exhibit differential roles in AAA initiation, progression, and healing.
- Potential strategies for detecting, assessing, and imaging macrophage subsets in AAA are identified.
Conclusions:
- Targeting specific monocyte and macrophage subsets may offer novel therapeutic strategies for AAA.
- Further research into macrophage biology is essential for developing effective drug-based treatments for AAA.
- Translational applications for macrophage imaging could improve AAA diagnosis and management.