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Related Experiment Videos

Thick Corpus Callosum in Children.

Aviv Schupper1,2, Osnat Konen2,3, Ayelet Halevy1,2

  • 1Department of Pediatric Neurology and Epilepsy Center, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Journal of Clinical Neurology (Seoul, Korea)
|April 14, 2017
PubMed
Summary

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A thick corpus callosum (TCC) is rare in children and often not linked to severe outcomes, unlike in fetuses. This study found TCC in 1.3% of pediatric MRIs, associated with conditions like NF-1 and epilepsy.

Area of Science:

  • Neuroimaging
  • Pediatric Neurology
  • Radiology

Background:

  • A thick corpus callosum (TCC) is a fetal brain malformation often linked to severe outcomes.
  • However, the clinical presentation and prognosis of TCC in older children appear significantly different.

Purpose of the Study:

  • To investigate the clinical presentation and associated conditions of TCC in children.
  • To determine if TCC in children carries the same grave prognosis as observed in fetuses.

Main Methods:

  • Retrospective review of pediatric brain MRI studies.
  • Inclusion criteria: diagnosis of TCC based on imaging.
  • Clinical data collection and corpus callosum measurement.

Main Results:

Keywords:
MRIcorpus callosumepilepsy/seizuresgeneticsneurofibromatosis

Related Experiment Videos

  • 34 children (1.3% of 2,552 MRIs) diagnosed with TCC.
  • Associated conditions included neurofibromatosis-1 (NF-1), epilepsy, macrocephaly capillary malformation (MCM) syndrome, and autistic spectrum disorder.
  • Measured CC thickness was comparable to adult norms; findings were not necessarily indicative of life-threatening conditions.

Conclusions:

  • TCC is a rare finding in children, associated with diverse neuropathologies.
  • Unlike fetal TCC, pediatric TCC is often a relatively benign finding.
  • The clinical significance of TCC differs markedly between fetal and pediatric populations.