[Postradiation change in the body's reaction to adrenaline]

In experiments with albino mongrel rats weighing 220-260 g a study was made of the influence of adrenaline on the cyclic nucleotide content of blood plasma at early times following 60Co-gamma-irradiation (75 Gy). The absence of the organism response to adrenaline is perhaps due to the development of postirradiation desensitization of beta-adrenergic system and inability to induce cAMP formation in a cell. The data are submitted confirming the influence of levamisole on the cyclic nucleotide level. The level of cGMP decreased in thymocytes and increased in blood plasma after the administration of the drug to irradiated animals.