Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial.

Nicolas Verheyen1, Astrid Fahrleitner-Pammer2, Evgeny Belyavskiy3

  • 1Department of Cardiology, Medical University of Graz, Graz, Austria.

Plos One
|April 14, 2017
PubMed

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vitamin K status has no influence on the effect of vitamin D supplementation on bone turnover and cardiovascular markers: a randomized controlled trial.

Frontiers in nutrition·2026
Same author

Validation of a deep learning model for bone fragility detection from conventional radiographs: an international cohort study.

EClinicalMedicine·2026
Same author

Tafamidis in women with wild-type transthyretin cardiac amyloidosis: an international cohort study.

European heart journal. Quality of care & clinical outcomes·2026
Same author

Association of lipid parameters with the development of disease complications in patients with limited cutaneous systemic sclerosis: a prospective exploratory cohort study.

Frontiers in nutrition·2026
Same author

Prognostic value of circulating glypican-4 in chronic heart failure.

Journal of molecular medicine (Berlin, Germany)·2026
Same author

Association of Inflammation-Based Ratios with Endothelial Dysfunction Markers and Clinical Parameters in Limited Cutaneous Systemic Sclerosis.

Journal of clinical medicine·2025
Summary

In primary hyperparathyroidism (pHPT), higher bone formation markers like P1NP, OC, and BALP correlate with improved left ventricular (LV) diastolic and systolic function. This suggests potential cardio-protective effects of bone turnover in pHPT.

Area of Science:

  • Endocrinology and Metabolism
  • Cardiology
  • Bone Biology

Background:

  • Observational studies indicate a connection between bone disease and left ventricular (LV) dysfunction, particularly in hyperparathyroid conditions.
  • Primary hyperparathyroidism (pHPT) is associated with metabolic changes that may impact cardiovascular health.

Purpose of the Study:

  • To investigate the relationship between circulating markers of bone turnover and LV function in patients with pHPT.
  • To test the hypothesis that bone turnover markers correlate with systolic and diastolic LV function.

Main Methods:

  • Cross-sectional analysis of 155 patients with pHPT from the EPATH Trial.
  • Multivariate linear regression models assessed correlations between bone turnover markers (P1NP, OC, BALP, CTX) and LV ejection fraction (LVEF) or early diastolic filling velocity (e').

Related Experiment Videos

  • Analyses were adjusted for multiple clinical and biochemical confounders.

    • Main Results:

    • N-terminal propeptide of procollagen type 1 (P1NP) showed independent positive correlations with LVEF (systolic function) and e' (diastolic function).
    • Osteocalcin (OC) and bone-specific alkaline phosphatase (BALP) were independently associated with improved e' (diastolic function).
    • Beta-crosslaps (CTX), a marker of bone resorption, did not correlate with LV function parameters.

    Conclusions:

    • Elevated bone formation markers (P1NP, OC, BALP) are paradoxically associated with better LV diastolic and, partly, systolic function in pHPT.
    • These findings suggest that stimulated bone formation may have beneficial cardiovascular effects in the context of hyperparathyroidism.
    • Further research is warranted to explore the potentially cardio-protective roles of enhanced bone formation in hyperparathyroidism.